Cotula cinerea Del. belongs to the family Asteraceae. It is widely used in the traditional medicinal system for the treatment of various ailments such as colic. Cotula cinerea Delile [family COMPOSITAE ] (stored under name); Verified by Not on Brocchia kotschyi; Cotula kotschyi; Cotula cinerea; Brocchia cinerea. Abstract: The phytochemical investigation of Cotula cinerea Del. afforded eighteen Keywords: Cotula cinerea Del.; Asteraceae; Flavonoids; Germacranolide.

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The extraction was achieved during six hours and the obtained oil yield 0. Higher concentrations were needed in the case of Salvia verbenaca extracts which showed the weakest cytotoxic effects. However, and despite the widespread use of these plants in Moroccan traditional folk cotulx, to the best of our knowledge, no information has been previously reported on the anticancer activity of Moroccan Cotula cinerea and Salvia verbenaca.

El Btaouri et al.

After 24 h incubation, cinere were then cootula with the essential oil of Cotula cinerea or its extracts hexane, ethyl acetate, and n -butanol in addition to those of Salvia verbenaca. This study is expected to be beneficial for clinical and traditional applications for Cotula cinerea as a remedy against cancer and opens new perspectives for further investigations on other types of cancer cell lines.

These corollas may be tubular, reduced or even absent. The antiproliferative activity of Cotula cinerea essential oil against the Vero tumor cell line could be due to presence of cytotoxic molecules in the oil.

Cotula – Wikipedia

The three extracts hexane, ethyl acetate, and n-butanol of each plant in addition to the essential oil of Cotula cinerea have then been assayed for their cytotoxic activity against RD and Vero cell lines using MTT assay.


Cotula cinerea which is of the Asteraceae family is a xerophytic plant widely distributed in sandy and desert grounds [ 11 ]. The exact mechanisms through which such compounds act in their cytotoxicity effect are not well known, but some tentative investigations suggested that these compounds could interrupt the life cycle cell, inducing the apoptosis pathways and inactivating the telomerase [ 6 ]. On the other hand, different results were obtained and Cotula cinerea essential oil was the most cytotoxic with cinwrea lowest IC 50 value However, and despite all the progress made, the cancer treatment remains a challenging task for both the patients and the medical staff.

Phillips Cotula pterocarpa DC. The essential oil of Cotula cinerea aerial parts was extracted by cinfrea using a Clevenger-type apparatus.

Huile essentielle de Santolina africana Jord. Abstract The objective of this work was to investigate the cytotoxicological effect of the extracts hexane, ethyl acetate, and n -butanol of Cotula cinerea and Salvia verbenaca in addition to the essential oil of Cotula cinerea.

Examination of the cytotoxic activity of the Cotula cinerea individual compounds would give crucial information regarding the exact mechanism of this plant in antitumor activity. Cotula vulgaris Levyns Cotula zeyheri Fenzl.

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In the case the RD cell line, the lowest IC 50 value References Publications referenced by this paper. These two species were obtained from the National Institute of Health, Rabat, Morocco, and were cultivated as previously described by Aneb et al.

Further investigations regarding the identification of bio-actives molecules responsible for these effects are needed. Chemical composition and Anticandidal properties of the essential oil isolated from aerial parts of Cotula Cinerea: Moreover, a molecule could have an effect on one type of tumor and not on others.


The noticed differences in the observed cytotoxicity of the investigated mixtures could obviously be due to the phytochemical composition of each extract. View at Google Scholar F. Morocco is rich in medicinal plants on which some studies have been focused on antitumor activities [ 7 — 10 ]. Views Read Edit View history. The maceration process was repeated twice during 24 h each in order to achieve an exhaustive extraction.

The genus can only be defined by looking at the corollas of their flowers. This was followed by the ethyl acetate extract and the essential oil with moderate effects against RD cell line and showed IC 50 values of It is thus important and imperative to find more effective drugs with a shorter application period. In the same conditions and for the Vero cell line, the best cytotoxic effect was observed with the essential oil followed by the hexane, the ethyl acetate, and the n -butanol extracts.

This was observed for both cell lines. In addition, these mixtures could act in a synergic or in an antagonism manner. Koch Cotula cinereum Cotula coronopifolia L.

Cotula cinerea

Correspondence should be addressed to Fatima-Ezzahrae Guaouguaou ; moc. The results are expressed as percentage of cytotoxicity versus the concentrations of the essential oil or extracts of both plants. The main constituents of the essential oil are Camphor, Camphene, Alpha-pinene, 3-carene, Thujone, 4-terpineol, Z -betafarnesene and santolinatriene.

Cotula is a genus cineres flowering plant in the sunflower family.